![]() The study included all patients presenting with chest pain suggestive of ACS and admitted for further treatment. The initial cohort contained 440 patients, but 12 (2.7%) patients were excluded because they did not have valid data for calculating the GRACE score or vital status 6 months after discharge. This study included 428 patients aged ≥18 years who were admitted to Hospital Sultanah Aminah, Johor Bahru, Malaysia, between January and April 2018 for acute coronary syndrome (ACS). 4 Thus, the aim of this study was to validate the GRACE risk score in an Asian medical centre to determine whether the probabilistic model can be used outside of the geographical and patient environment in which it was created. We must be mindful of the geographical differences and patient characteristics in the original GRACE study when applying this risk score to other populations, with validation required to avoid erroneous results in risk calculations. It uses a predictive logistic model with eight prognostic variables ( Supplementary Material Figure 1) to determine a patient’s probability of death due to any cause during the first 6 months after discharge. The GRACE risk score predicts 6-month mortality after a patient has been discharged following hospital admission for ACS. The GRACE registry, a global registry of ACS patients from 94 hospitals in 14 countries, developed two models to estimate the risk of in-hospital and 6-month mortality among all patients with ACS. There are various risk scores to predict mortality risk among patients admitted for acute coronary syndrome (ACS), such as the Thrombolysis in MI (TIMI) score, Global Registry of Acute Coronary Events (GRACE) risk score and the Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin (eptifibatide) Therapy (PURSUIT) score. Conclusion: This study validated the GRACE score for predicting 6-month mortality among patients admitted to an Asian medical centre for ACS and recommended that it is used routinely The GRACE risk score was calibrated and validated, showing an adequate capacity for discrimination with a receiver operating characteristic area under the curve of 0.831 (95% CI p<0.001). By 6 months after discharge, 66 (15%) patients had died. Results: Of the 428 patients in this study, 92 (21.5%) were admitted for STelevation MI (STEMI), 128 (29.9%) were admitted for non-STEMI and 208 (48.6) were admitted for unstable angina. The survival status of patients 6 months after hospital discharge was calculated using the GRACE risk score, and the validity of the GRACE risk score was evaluated by assessing its calibration (Hosmer–Lemeshow test) and discriminatory capacity. ![]() Methods: This study validated the GRACE score in a contemporary cohort of 428 patients aged ≥18 years admitted to Hospital Sultanah Aminah Johor Bahru between January and April 2018 for ACS. Background: The Global Registry of Acute Coronary Syndrome (GRACE) risk score is used to provide an estimate of 6-month mortality among patients admitted for acute coronary syndrome (ACS). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |